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Publications

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2026 · A  |  Preprint


Characterization of tri-culture alveolar-like organoids to study fibrotic lung diseases


Guo T.J.F., Meng Y., Kim S., Machiri T., Miscampbell A., Lau K.S.K., Gibbons C., Penton M.R., Lee C.P.S., Li I.T.S., Goobie G.C., Halayko A.J., Ryerson C.J., Carlsten C., Ryu M.H., and Osei E.T (2026)
bioRxiv preprint

DOI: 10.64898/2026.09.04.749305
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2026 · B


Generation of 3D Collagen-Embedded A549/MRC-5 Alveolar Organoids using a Mechanical Cell-Stretching Bioreactor


Guo T.J.F., Al Yazeedi S., Baher J.Z., Yee L., Cheung C., Sin D.D., and Osei E.T (2026)

DOI: 10.3791/69447
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2025 · A


Editorial: Next generation in vitro models to study chronic pulmonary diseases, volume II

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Guo T.J.F , Osei E.T., Faiz. A., Pouwels S.D. (2025)

DOI: 10.3389/fmed.2025.1683514
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2025 · B

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Dynamic mechanical stimulation of alveolar epithelial-fibroblast models using the Flexcell tension system to study of lung disease mechanisms

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Al Yazeedi S, Guo T.J.F, Joban S., Abokor A.F., Baher J.Z., Yee L., Cheung C., Sin D.D., and Osei E.T. (2025)
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DOI: 10.3389/fmed.2025.1552803​
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2025 · C

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Exploring Multi-Organ Crosstalk via the TissUse HUMIMIC Chip System: Lessons Learnt So Far

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Abokor F.A., Yazeedi SAl., Baher J.Z., Cheung C., Don D.D. Osei E.T (2025)
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DOI: 10.1002/bit.70031​
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2025 · D

 
Establishing a 3D Vascularized Tri-Culture Model of the Human Airways via a Digital Light Processing Bioprinter
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Phogat S., Guo T. J. F., Thiam F. Osei, E.T. (2025)

DOI: 10.1002/bit.29013

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2024 · A

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Interleukin-1α inhibits transforming growth factor-β1 and β2-induced extracellular matrix production, remodeling and signaling in human lung fibroblasts: Master regulator in lung mucosal repair

 
Usman K., Fouadi M., Nwozor K.O., Aminazadeh F., Nair P., Luo H., Sin D.D., Osei, E.T., and Hackett T.L. (2024)
 
DOI: 10.1016/j.matbio.2024.06.007​
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2024 · B

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The effect of the Mechanodynamic lung environment on fibroblast phenotype via the Flexcell. BMC Pulmonary Medicine

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Al Yazeedi S., Abokor A.F, Brussow J., Thiam F., Phogat S., Osei E.T (2024)

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DOI: 10.1186/s12890-024-03167-7

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2023 · A

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In vitro co-culture studies and the crucial role of fibroblast-immune cell crosstalk in IPF pathogenesis

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Thiam F., Phogat S., Abokor F., Osei E.T. (2023)​
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DOI: 10.1186/s12931-023-02608-x
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2023 · B

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Next generation in vitro models to study chronic pulmonary diseases

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Thiam F., Faiz A., Pouwels S.D. and Osei E.T. (2023)​
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DOI: 10.3389/fmed.2023.1338939
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2023 · C

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3D in vitro hydrogel models to study the human lung extracellular matrix and fibroblast function

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Phogat S., Thiam F., Al Yazeedi S., Abokor F., and Osei E. T. (2023)​
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DOI: 10.1186/s12931-023-02548-6
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2023 · D

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Epithelial-fibroblast interactions in IPF: lessons from in vitro co-culture studies

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Brussow J., Feng K., Thiam F. and Osei E.T. (2023)​
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DOI: 10.1016/j.diff.2023.09.001
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2023 · E

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The contribution of reticular basement membrane proteins to basal airway epithelial attachment, spreading and barrier formation: implications for airway remodeling in asthma

 

Hsieh A., Yang C. X., Al-Fouadi M., Nwozor, K. O., Osei E.T. and Hackett T.L. (2023)​
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DOI: 10.3389/fmed.2023.1214130
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2023 · F

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Understanding fibroblast-immune cell interactions via co-culture models and their role in asthma pathogenesis

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Thiam F., Al Yazeedi S., Feng K., Phogat S., Demirsoy E., Brussow J., Abokor F.A., and Osei E.T. (2023)
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DOI: 10.1371/journal.pone.0229278
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2022 · A

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Hedgehog Signaling as a Therapeutic Target for Airway Remodeling and Inflammation in Allergic Asthma

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Tam A., Osei E.T., Cheug C.Y., Hughes M., Yang C.X., McNagny K.M., Dorscheid D. R., Singhera K. G., Hallstrand T. S., Warner S., Hogg J.C., Hackett T.L., Lim C.J. and Sin D.D. (2022)
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DOI: 10.3390/cells11193016
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2022 · B

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Canadian lung tissue biobank with associated clinical data supporting respiratory research for four decades

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Sutherland D.P., Vasilescu D.M., Osei E.T., Coxson N.E., Yang C.X., Booth S., Coxson H.O., Elliot W.M., Paré P.D., Hogg J.C, and Hackett T.L. (2022)
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  DOI: 10.1080/24745332.2021.1878007
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2022 · C

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The Role of the Dynamic Lung Extracellular Matrix Environment on Fibroblast Morphology and Inflammation

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Hackett T.L, Vriesde N.R.T.F, Al-Fouadi M, Mostaco-Guidolin L, Maftoun D, Hsieh A, Coxson N, Usman K, Sin D.D, Booth S, Osei E.T. (2022)
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 DOI: 10.3390/cells11020185
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2021 · A

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Modeling Extracellular Matrix-Cell Interactions in Lung Repair and Chronic Disease

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Hackett T.-L and Osei E.T. (2021)
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DOI: 10.3390/cells10082145
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2021 · B

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Second harmonic generation imaging of collagen scaffolds within the alveolar ducts of healthy and emphysematous mouse lungs

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Mostaco-Guidolin L., Loube J., Barlow A., Osei E.T., Vasilescu M.D., Hsieh A., AL-Fouadi M., Scott A., Mitzner W. and Hackett T.L. (2021)
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DOI: 10.1007/s00418-020-01959-6
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2020 · A

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Epithelial-mesenchymal crosstalk in COPD: An update from in vitro model studies

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Osei E.T. and Hackett T.L. (2020)
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DOI: 10.1016/j.biocel.2020.105775
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2020 · C

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Epithelial-interleukin-1 inhibits collagen formation by airway fibroblasts: Implications for asthma

 

Osei E.T., Mostaço-Guidolin L.B., Hsieh A., Wang M., Warner S., AL-Fouadi M., Cole D.J., Maksym G.N., Timens W., Hallstrand T., Brandsma C.A., Heijink I.H., and Hackett T.L. (2020)
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DOI: 10.1038/s41598-020-65567-z
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2020 · D

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Super resolution measurement of collagen fibers in biological samples: Validation of a commercial solution for multiphoton microscopy

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Barlow M.A., Mostaço-Guidolin L.B., Osei E.T., Booth S., and Hackett T.L (2020)
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DOI: 10.1371/journal.pone.0229278
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2019 · A

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Current perspectives on the role of interleukin-1 signalling in the pathogenesis of asthma and COPD

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Osei E.T., Brandsma C-A, Timens W, Heijink I.H. and Hackett T-L. (2019)
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DOI:10.1183/13993003.00563-2019 
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2019 · B

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Defective Fibrillar Collagen Organization by Fibroblasts Contributes to Airway Remodeling in Asthma

 

*​Mostaco-Guidolin L.B, *Osei E.T. Ullah J., Hajimohammadi S., Li X., Li V., AL-Fouadi M., Yang Y., Shaheen, F., Chu F., Cole D.J., Brandsma C-A., Heijink I.H., Maksym G.N., Walker D. and Hackett TL (2019)

*co-first Author​
DOI: 10.1164/rccm.201810-1855OC
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2017 · A

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The role of epithelial-fibroblast communication in asthma and COPD

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Osei E.T. (2017)​
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DOI: 10.14288/1.0355543
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2017 · B

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miR-146a-5p plays an essential role in the aberrant epithelial–fibroblast cross-talk in COPD

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Osei E.T., Florez-Sampedro L, Tasena H, Faiz A, Noordhoek JA, Timens W, Postma DS, Hackett TL, Heijink IH, Brandsma CA. (2017)
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DOI: 10.1183/13993003.02538-2016
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2016 · A

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Interleukin-1α drives the dysfunctional cross-talk of the airway epithelium and lung fibroblasts in COPD

 

Osei E.T., Noordhoek J.A., Hackett T.L., Spanjer A.I.R., Postma S.D., Timens, W., Brandsma C-A and Heijink I.H. (2016)
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DOI: 10.1183/13993003.01911-2015
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2015 · A

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Unravelling the complexity of COPD by microRNAs: it's a small world after all | European Respiratory Society

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Osei E.T., Florez-Sampedro L., Timens W., Postma S.D., Heijink I.H. and Brandsma C-A. (2015)
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DOI: 10.1183/13993003.02139-2014 
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