Publications
24.
Phogat S, Guo TJF, Thiam F, Osei E.T. (2025) Establishing a 3D Vascularized Tri-Culture Model of the Human Airways via a Digital Light Processing Bioprinter; Biotechnology and Bioengineering; https://doi.org/10.1002/bit.29013
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23.
Usman, K.; Fouadi, M.; Nwozor, K.O., Aminazadeh F., Nair P., Luo H., Sin D.D., Osei, E.T., and Hackett, T.L. (2024) Interleukin-1α inhibits transforming growth factor-β1 and β2-induced extracellular matrix production, remodeling, and signaling in human lung fibroblasts: Master regulator in lung mucosal repair. Matrix Biol. 2024 Sep;132:47-58. https://doi.org/10.1016/j.matbio.2024.06.007
22.
Al Yazeedi S, Abokor AF, Brussow J, Thiam F, Phogat S, and Osei E.T. (2024) The effect of the mechanodynamic lung environment on fibroblast phenotype via the Flexcell. BMC Pulm Med. 2024 Jul 27;24(1):362. https://doi.org/10.1186/s12890-024-03167-7​​​​​​
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21.
Thiam F., Phogat S., Abokor F., Osei E. T. (2023). In vitro co-culture studies and the crucial role of fibroblast-immune cell crosstalk in IPF pathogenesis. Respiratory Research. 24: 298. http://dx.doi.org/10.1186/s12931-023-02608-x
20.
Thiam F., Faiz A., Pouwels S.D. and Osei E.T. (2023). Next generation in vitro models to study chronic pulmonary diseases. Frontiers in Medicine. 10-2023 http://dx.doi.org/10.3389/fmed.2023.1338939
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​19.
Phogat S, Thiam F., Al Yazeedi S., Abokor F., and Osei E T. (2023). 3D in vitro hydrogel models to study the human lung extracellular matrix and fibroblast function. Respiratory Research. 24: 242. http://dx.doi.org/10.1186/s12931-023-02548-6
​​18.
Brussow J., Feng K., Thiam F. and Osei E.T. (2023). Epithelial-fibroblast interactions in IPF: lessons from in vitro co-culture studies. Differentiation. 134: 11-19. http://dx.doi.org/10.1016/j.diff.2023.09.001
17.
Hsieh, A. Yang, C. X. Al-Fouadi, M. Nwozor, K. O. Osei, E. T., and Hackett, T. L. (2023), The contribution of reticular basement membrane proteins to basal airway epithelial attachment, spreading, and barrier formation: implications for airway remodeling in asthma. Frontiers in Medicine 10, 1214130 https://doi.org/10.3389/fmed.2023.1214130
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16.
Thiam F., Al Yazeedi S., Feng K., Phogat S., Demirsoy E., Brussow J., Abokor F.A., and Osei E.T. (2023) Understanding fibroblast-immune cell interactions via co-culture models and their role in asthma pathogenesis. Frontiers Immunology 23:14:1128023 https://doi.org/10.3389/fimmu.2023.1128023
15.
Tam A., Osei E.T., Cheug C.Y., Hughes M., Yang C.X., McNagny K.M., Dorscheid D. R., Singhera K. G., Hallstrand T. S., Warner S., Hogg J.C., Hackett T.L., Lim C.J. and Sin D.D. (2022). Hedgehog signaling as a therapeutic target for airway remodeling and inflammation in allergic asthma. Cells. 11(19): 3016. https://doi.org/10.3390/cells11193016
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14.
Sutherland D.P., Vasilescu D.M., Osei E.T., Coxson N.E., Yang C.X., Booth S., Coxson H.O., Elliot W.M., Paré P.D., Hogg J.C, and Hackett T.L. (2022). Canadian lung tissue biobank with associated clinical data supporting respiratory research for four decades. Canadian Journal of Respiratory, Critical Care, and Sleep Medicine. https://doi.org/10.1080/24745332.2021.1878007
13.
Hackett T.L, Vriesde N.R.T.F, Al-Fouadi M, Mostaco-Guidolin L, Maftoun D, Hsieh A, Coxson N, Usman K, Sin D.D, Booth S, Osei E.T. (2022). The role of the dynamic lung extracellular matrix environment on fibroblast morphology and inflammation. Cells. 11(2): 185. https://doi.org/10.3390/cells11020185
12.
Hackett T.-L and Osei E.T. (2021). Modeling Extracellular Matrix-Cell interactions in Lung repair and chronic disease. Cells 10(8): 2145. https://doi.org/10.3390/cells10082145
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11.
Mostaco-Guidolin L., Loube J., Barlow A., Osei E.T., Vasilescu M.D., Hsieh A., AL-Fouadi M., Scott A., Mitzner W. and Hackett T.L. (2021). Second Harmonic Generation Imaging of collagen within alveolar ducts in cleared emphysematous mouse lungs. Histochemistry and Cell Biology. 155(2): 279-289 https://doi.org/10.1007/s00418-020-01959-6
10.
Osei E.T. and Hackett T.L. (2020). Epithelial-Mesenchymal crosstalk in COPD: An update from in vitro model studies. International Journal of Biochemistry & Cell Biology. 125: 105775 https://doi.org/10.1016/j.biocel.2020.105775
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9.
Osei E.T., Booth S, Hackett T-L. (2020). What have in vitro co-culture models taught us about the contribution of epithelial-mesenchymal interactions to airway inflammation and remodeling in asthma? Cells. 9(7): 1694. https://doi.org/10.3390/cells9071694
8.
Osei E.T., Mostaço-Guidolin L.B., Hsieh A., Wang M., Warner S., AL-Fouadi M., Cole D.J., Maksym G.N., Timens W., Hallstrand T., Brandsma C.A., Heijink I.H., and Hackett T.L. (2020). Epithelial- interleukin-1 inhibits collagen formation by airway fibroblasts: Implications for asthma. Scientific Reports, 10(0): 8721 https://doi.org/10.1038/s41598-020-65567-z
7.
Barlow M.A., Mostaço-Guidolin L.B., Osei E.T., Booth S., and Hackett T.-L. (2020). Super resolution measurement of collagen fibers in biological samples: Validation of a commercial solution for multiphoton microscopy. PLOS ONE. 15(2): e0229278 https://doi.org/10.1371/journal.pone.0229278
6.
Osei E.T., Brandsma C-A, Timens W, Heijink I.H. and Hackett T-L. (2019). Current perspectives on the role of Interleukin-1 signaling in the pathogenesis of asthma and COPD. European Respiratory Journal, 55: 1900563. https://doi.org/10.1183/13993003.00563-2019
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5.
#Osei E.T., #Mostaco-Guidolin L.B*, Ullah J., Hajimohammadi S., Li X., Li V., AL-Fouadi M., Yang Y., Shaheen, F., Chu F., Cole D.J., Brandsma C-A., Heijink I.H., Maksym G.N., Walker D. and Hackett TL (2019). Defective fibrillar collagen organization by fibroblasts contributes to airway remodeling in asthma. American Journal of Respiratory and Critical Care Medicine, 200(4): 431-443. https://doi.org/10.1164/rccm.201810-1855OC (#co-first author)
4.
Osei E.T. (2018). De rol van epitheel-fibroblast communicatie in astma en COPD. Nederlands Tijdschriftvoor Allergie & Astma (NTvAA). 18: 91-93. https://www.ariez.nl/wp- content/uploads/2018/08/91-3.pdf​
3.
Osei E.T., Florez-Sampedro L, Tasena H, Faiz A, Noordhoek JA, Timens W, Postma DS, Hackett TL, Heijink IH, Brandsma CA. (2017). miR-146a-5p plays an essential role in the aberrant epithelial-fibroblast crosstalk in COPD. European Respiratory Journal. 49(5): 1-11. https://doi.org/10.1183/13993003.02538-2016
​​2.
Osei E.T., Noordhoek J.A., Hackett T.L., Spanjer A.I.R., Postma S.D., Timens, W., Brandsma C-A and Heijink I.H. (2016). Interleukin-1α drives the dysfunctional crosstalk of the airway epithelium and lung fibroblasts in COPD. European Respiratory Journal. 48(2): 359-369 https://doi.org/10.1183/13993003.01911-2015
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1.
Osei E.T., Florez-Sampedro L., Timens W., Postma S.D., Heijink I.H. and Brandsma C-A. (2015). Unravelling the complexity of COPD by microRNAs; it’s a small world after all. European Respiratory Journal. 46(3): 807 – 818 https://doi.org/10.1183/13993003.02139-2014
