OSEI LAB
The Osei / Lung Bioartificial Model Lab
Research & Themes
We develop biomimetic human lung models to study how cells, the extracellular matrix, and environmental exposures shape lung health and disease.
Cell and matrix crosstalk
Human lung models reveal how epithelial, immune and stromal cells interact with the matrix to drive inflammation, repair and fibrosis in asthma and COPD.
PMIDs: 27418555 · 28546273 · 32457454
Mechanics of the breathing lung
We stretch 2D and 3D lung models to study how normal breathing and disease-related strain change cell behaviour and communication.
PMIDs: 35053300 · 39068387
Lung-gut and multi-organ crosstalk
Connected lung and gut models reveal how the microbiome and treatments in one organ influence another.
PMIDs: 34440917 · 40726012
Patient tissue and translation
We compare engineered lung models with patient-derived tissue to test whether laboratory findings reflect human disease and improve our models. PMIDs: 32679790 · 30950644
BREATHE-OK lung biobank
BREATHE-OK links Okanagan airway, blood and lung samples with clinical and environmental data to study wildfire smoke and other regional exposures.
Immunobiology Excellence Cluster
At UBC Okanagan, we use 3D models to study how macrophages, lung cells and matrix drive fibrosis.
Team: Drs. Li, Menard, Hughes & Piantanida and Frattolin.
LAB Group & Research Hub Collaborations
Air Pollution Exposure Lab
With Dr. Min Hyung Ryu, we connect controlled human exposure studies with engineered lung models to reveal how wildfire smoke and other pollutants cause injury.
Rheault Lab
With Dr. M. Rheault, we develop insect epithelial cultures and compare chemical transport across insect and mammalian tissues.
Haston Lab
With Dr. Christina Haston, we identify biomarkers and genes to improve biomimetic models of radiation-induced lung disease.
Galatek
We are evaluating automated liquid handling, organoid culture and confocal imaging systems for research and teaching.
TEAM HUB Ottawa
We collaborate on advanced 3D tissue models, imaging and analysis to better understand tissue biology and disease.
Apricell Biotechnology
We use the TruSphere™ insert for rapid, uniform spheroid and organoid culture in cancer and lung disease research.
Lab Equipment
A snapshot of the equipment in the Osei lab
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PRUSA SL1S SLA 3D printer
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FORM 3B SLA 3D Printer
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PRUSA MK3 3D Filament printer
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3D Extrusion and DLP Bioprinters
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LUMENX+ DLP Bioprinter
BIOX Extrusion-based-bioprinter
FLEXCELL 6000 Tissue Mechanical Bioreactor
TissUse HUMIMIC multi-organ-on-chip system
Cryostorage: -80 C freezer and liquid nitrogen storage
Cryostorage: -20 C freezer and cold storage
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BSL2 Cell Culture Cabinet & equipment
Fluorescent & brightfield microscopes & automated cell counters for culture & analysis
Specialised peristaltic and syringe pumps for microfluidic assays
Incubators for BSL2 Cell culture
Centrifuges & bench-top equipment for molecular techniques
Want to join the Osei Lab?
The lab is currently at capacity and is not accepting new students or trainees. Exceptional candidates whose experience closely aligns with our research may contact Dr. Osei to discuss potential opportunities. Space constraints mean that a position cannot be guaranteed.
Please contact Dr. Osei before submitting a formal application. Learn more about the UBCO Biology Graduate Program.